A Population Model of Gentamicin Made with a New Nonparametric Em Algorithm
نویسنده
چکیده
A nonparametric EM (NPEM) algorithm for population pharmacokinetic modeling has been implemented as a computer program for the IBM PC and compatible machines. It computes the joint probability density function (PDF) for a 1 compartment pharmacokinetic model with intravenous dosing. It can operate using data of only one serum level per patient. The program utilizes patient data files from the USC*PACK PC clinical programs (1). Output includes a 3D plot of the joint PDF, two marginal PDF plots, means, variances, modes, quartiles, skewness, kurtosis, and covariance and correlation coefficient between parameters. Results can be entered into population files for use with the USC*PACK PC clinical programs. The first clinical study with this algorithm, of patients receiving intravenous gentamicin, is described. Results are compared with the standard 2-stage algorithm. Various parameterizations and sparse data sets are analyzed. The NPEM PC computer program permits population pharmacokinetic modeling in community hospitals.
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